Development and Validation of Rapid, Timesaving, and Cost-effective UHPLC Method for Simultaneous Quantification of Cinnarizine, its Five Specified Impurities, Two Degradation Products and Two Antioxidants

This article explains the developed and validated rapid, timesaving, cost-effective UHPLC method for simultaneous quantification of cinnarizine, its five specified impurities (Impurity-A to E), two degradation products (cinnamyl piperazine benzhydrol), antioxidants (methylparaben propylparaben). Furthermore, when coupled with a mass spectrometer, proposed provides additional advantages confirmation results correct identification based on molecular weight. All analytes were eluted within 15 minutes an ACQUITY, UPLC, BEH C18 (150 mm x 2.1 mm, 1.7 µm) column at 40.0°C by using mobile phases containing different compositions 10 mM ammonium acetate, acetonitrile, acetic acid in gradient elution mode. The linearity curves impurities, showed good correlation coefficient 0.999 lower detection limit (0.1125 μg/ mL) (0.1875 μg/mL) 230 nm. A forced study spiked unspiked solutions proved their specificity improvements significance. involves flow rate (0.35 mL/min.) shorter run time, which faster analysis, reduces wastage, cost, specifies greener advantages. outcome validation as per ICH guidelines that is accurate, precise, timesaving all active pharmaceutical ingredient, tablets, capsules, oral suspension cinnarizine.